Non-Canonical Cell Death Induced by P53

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Dec 13

PMID 27941671

Citations 71

Authors

Atul Ranjan

Tomoo Iwakuma

Affiliations

Soon will be listed here.

Abstract

Programmed cell death is a vital biological process for multicellular organisms to maintain cellular homeostasis, which is regulated in a complex manner. Over the past several years, apart from apoptosis, which is the principal mechanism of caspase-dependent cell death, research on non-apoptotic forms of programmed cell death has gained momentum. p53 is a well characterized tumor suppressor that controls cell proliferation and apoptosis and has also been linked to non-apoptotic, non-canonical cell death mechanisms. p53 impacts these non-canonical forms of cell death through transcriptional regulation of its downstream targets, as well as direct interactions with key players involved in these mechanisms, in a cell type- or tissue context-dependent manner. In this review article, we summarize and discuss the involvement of p53 in several non-canonical modes of cell death, including caspase-independent apoptosis (CIA), ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis, as well as its role in efferocytosis which is the process of clearing dead or dying cells.

Citing Articles

Novel anoikis-related diagnostic biomarkers for aortic dissection based on machine learning.

Zhang H, Ouyang Z, Zhou T, Su F, Wang M Sci Rep. 2024; 14(1):31314.

PMID: 39732886 PMC: 11682115. DOI: 10.1038/s41598-024-82655-6.

Baicalin Ameliorates Depression-like Behaviors via Inhibiting Neuroinflammation and Apoptosis in Mice.

Yi Y, Liu G, Li Y, Wang C, Zhang B, Lou H Int J Mol Sci. 2024; 25(19).

PMID: 39408591 PMC: 11476789. DOI: 10.3390/ijms251910259.

Ferroptosis-associated genes and compounds in renal cell carcinoma.

He C, Li Q, Wu W, Liu K, Li X, Zheng H Front Immunol. 2024; 15:1473203.

PMID: 39399506 PMC: 11466770. DOI: 10.3389/fimmu.2024.1473203.

Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure.

Xing Z, Zhang C, Liu L World J Gastroenterol. 2024; 30(33):3791-3798.

PMID: 39351426 PMC: 11438622. DOI: 10.3748/wjg.v30.i33.3791.

CEP-1347 Boosts Chk2-Mediated p53 Activation by Ionizing Radiation to Inhibit the Growth of Malignant Brain Tumor Cells.

Mitobe Y, Suzuki S, Nakamura K, Nakagawa-Saito Y, Takenouchi S, Togashi K Int J Mol Sci. 2024; 25(17).

PMID: 39273420 PMC: 11395301. DOI: 10.3390/ijms25179473.

References

Criollo A, Dessen P, Kroemer G . DRAM: a phylogenetically ancient regulator of autophagy. Cell Cycle. 2009; 8(15):2319-20. DOI: 10.4161/cc.8.15.9153. View

Newton K, Dugger D, Wickliffe K, Kapoor N, de Almagro M, Vucic D . Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014; 343(6177):1357-60. DOI: 10.1126/science.1249361. View

Laster S, Wood J, Gooding L . Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol. 1988; 141(8):2629-34. View

McIlwain D, Berger T, Mak T . Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 2013; 5(4):a008656. PMC: 3683896. DOI: 10.1101/cshperspect.a008656. View

Tasdemir E, Maiuri M, Galluzzi L, Vitale I, Djavaheri-Mergny M, DAmelio M . Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 2008; 10(6):676-87. PMC: 2676564. DOI: 10.1038/ncb1730. View

Jiang L, Kon N, Li T, Wang S, Su T, Hibshoosh H . Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015; 520(7545):57-62. PMC: 4455927. DOI: 10.1038/nature14344. View

Galluzzi L, Kroemer G . Necroptosis: a specialized pathway of programmed necrosis. Cell. 2008; 135(7):1161-3. DOI: 10.1016/j.cell.2008.12.004. View

Wang E, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum L . p53 mediates autophagy and cell death by a mechanism contingent on Bnip3. Hypertension. 2013; 62(1):70-7. DOI: 10.1161/HYPERTENSIONAHA.113.01028. View

Maiuri M, Criollo A, Tasdemir E, Vicencio J, Tajeddine N, Hickman J . BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy. 2007; 3(4):374-6. DOI: 10.4161/auto.4237. View

10.

Majno G, Joris I . Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol. 1995; 146(1):3-15. PMC: 1870771. View

11.

Shimada Y, Klionsky D . Autophagy contributes to lysosomal storage disorders. Autophagy. 2012; 8(5):715-6. PMC: 3625119. DOI: 10.4161/auto.19920. View

12.

Taylor B, McNeely S, Miller H, Lehmann G, McCabe Jr M, States J . p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1. J Pharmacol Exp Ther. 2006; 318(1):142-51. DOI: 10.1124/jpet.106.103077. View

13.

Dixon S, Lemberg K, Lamprecht M, Skouta R, Zaitsev E, Gleason C . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012; 149(5):1060-72. PMC: 3367386. DOI: 10.1016/j.cell.2012.03.042. View

14.

Gupta S, Radha V, Furukawa Y, Swarup G . Direct transcriptional activation of human caspase-1 by tumor suppressor p53. J Biol Chem. 2001; 276(14):10585-8. DOI: 10.1074/jbc.C100025200. View

15.

Edinger A, Thompson C . Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol. 2004; 16(6):663-9. DOI: 10.1016/j.ceb.2004.09.011. View

16.

Ye H, Cande C, Stephanou N, Jiang S, Gurbuxani S, Larochette N . DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol. 2002; 9(9):680-4. DOI: 10.1038/nsb836. View

17.

Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K . De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet. 2013; 45(4):445-9, 449e1. DOI: 10.1038/ng.2562. View

18.

Taylor W, DePrimo S, Agarwal A, Agarwal M, Schonthal A, Katula K . Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell. 1999; 10(11):3607-22. PMC: 25646. DOI: 10.1091/mbc.10.11.3607. View

19.

Mizushima N . Autophagy: process and function. Genes Dev. 2007; 21(22):2861-73. DOI: 10.1101/gad.1599207. View

20.

Chen Z, Xiao Z, Chen J, Ng S, Sowin T, Sham H . Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Mol Cancer Ther. 2003; 2(6):543-8. View