Cryptotanshinone Targets Tumor-initiating Cells Through Down-regulation of Stemness Genes Expression

Overview

Journal Oncol Lett

Specialty Oncology

Date 2016 Jun 18

PMID 27313698

Citations 9

Authors

Ying Zhang

Stephanie M Cabarcas

J I Zheng

Lei Sun

Lesley A Mathews

Xiaohu Zhang

Hongsheng Lin

William L Farrar

Affiliations

Soon will be listed here.

Abstract

Recent evidence indicates that tumor-initiating cells (TICs), also called cancer stem cells (CSCs), are responsible for tumor initiation and progression, therefore representing an important cell population that may be used as a target for the development of future anticancer therapies. In the present study, Cryptotanshinone (CT), a traditional Chinese herbal medicine, was demonstrated to regulate the behaviors of LNCaP prostate cells and prostate LNCaP TICs. The results demonstrate that treatment with CT alters cellular proliferation, cell cycle status, migration, viability, colony formation and notably, sphere formation and down-regulation of stemness genes (Nanog, OCT4, SOX2, β-catenin, CXCR4) in TICs. The present study demonstrates that CT targets the LNCaP CD44+CD24- population that is representative of prostate TICs and also affects total LNCaP cells as well via down-regulation of stemness genes. The strong effect with which CT has on prostate TICs suggests that CT may potentially function as a novel natural anticancer agent that specifically targets TICs.

Citing Articles

Molecular Mechanism of Tanshinone against Prostate Cancer.

Li W, Huang T, Xu S, Che B, Yu Y, Zhang W Molecules. 2022; 27(17).

PMID: 36080361 PMC: 9457553. DOI: 10.3390/molecules27175594.

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases.

Guo X, Ma R, Wang M, Lau B, Chen X, Li Y Front Pharmacol. 2022; 13:971444.

PMID: 36046823 PMC: 9420941. DOI: 10.3389/fphar.2022.971444.

Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis.

Li X, Jia Q, Zhou Y, Jiang X, Song L, Wu Y Exp Hematol Oncol. 2022; 11(1):2.

PMID: 35057866 PMC: 8781032. DOI: 10.1186/s40164-022-00255-4.

Novel function of THEMIS2 in the enhancement of cancer stemness and chemoresistance by releasing PTP1B from MET.

Huang W, Yen J, Sung Y, Tung S, Chen P, Chu P Oncogene. 2022; 41(7):997-1010.

PMID: 34974522 PMC: 8837547. DOI: 10.1038/s41388-021-02136-2.

Cryptotanshinone attenuates the stemness of non-small cell lung cancer cells via promoting TAZ translocation from nuclear to cytoplasm.

Jin L, Wu Z, Wang Y, Zhao X Chin Med. 2020; 15:66.

PMID: 32612672 PMC: 7325009. DOI: 10.1186/s13020-020-00348-4.

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