IgA1 Glycosylation Is Heritable in Healthy Twins

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2016 Jun 18

PMID 27313232

Citations 14

Authors

Hannah J Lomax-Browne

Alessia Visconti

Charles D Pusey

H Terence Cook

Tim D Spector

Matthew C Pickering

Mario Falchi

Affiliations

Soon will be listed here.

Abstract

IgA nephropathy (IgAN) is the most common form of primary GN and an important cause of kidney failure. Characteristically, patients with IgAN have increased serum levels of undergalactosylated IgA1 (gd-IgA1). To assess the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals, we determined serum IgA and gd-IgA1 levels by ELISA in a sample of 148 healthy female twins, including 27 monozygotic and 47 dizygotic pairs. Using the classic twin model, we found the heritability of serum gd-IgA1 and IgA levels to be 80% (95% confidence interval, 66% to 89%) and 46% (95% confidence interval, 15% to 69%), respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.

Citing Articles

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