Lessons from Making the Structural Classification of Proteins (SCOP) and Their Implications for Protein Structure Modelling

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2016 Jun 11

PMID 27284063

Citations 2

Authors

Antonina Andreeva

Affiliations

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Abstract

The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling.

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