Sarcopenia/Muscle Mass is Not a Prognostic Factor for Short- and Long-Term Outcome After Esophagectomy for Cancer

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2016 Jun 9

PMID 27272482

Citations 45

Authors

Brechtje A Grotenhuis

Joel Shapiro

Stefan van Adrichem

Marianne de Vries

Marcel Koek

Bas P L Wijnhoven

J Jan B van Lanschot

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have suggested that sarcopenia is a prognostic risk indicator of postoperative complications and predicts survival in cancer patients. The aim of this study is to investigate whether sarcopenia is associated with postoperative short-term outcome (morbidity and mortality) and long-term survival in patients undergoing esophagectomy for cancer after neoadjuvant chemoradiotherapy.

Methods: All patients who underwent neoadjuvant chemoradiotherapy followed by esophagectomy for cancer, and of whom an adequate CT scan was available, were included in the current study. The presence of sarcopenia was defined by CT imaging using cut-off values of the total cross-sectional muscle tissue measured transversely at the third lumbar level.

Results: A total number of 120 patients were eligible for analysis. Almost half of the patients (N = 54, 45 %) were classified as having sarcopenia; 24 sarcopenic patients (44 %) had overweight and 5 sarcopenic patients (9 %) were obese. Overall morbidity and mortality rate did not differ significantly between sarcopenic and non-sarcopenic patients, nor did long-term overall or disease-free survival. Also sarcopenic obesity was not associated with worse outcome.

Conclusion: The presence of sarcopenia was not associated with a negative short- and long-term outcome in this selected group of esophageal cancer patients after neoadjuvant chemoradiotherapy followed by esophagectomy.

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References

Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):M146-56. DOI: 10.1093/gerona/56.3.m146. View

Grotenhuis B, Wijnhoven B, Hotte G, van der Stok E, Tilanus H, van Lanschot J . Prognostic value of body mass index on short-term and long-term outcome after resection of esophageal cancer. World J Surg. 2010; 34(11):2621-7. PMC: 2949552. DOI: 10.1007/s00268-010-0697-8. View

Yip C, Goh V, Davies A, Gossage J, Mitchell-Hay R, Hynes O . Assessment of sarcopenia and changes in body composition after neoadjuvant chemotherapy and associations with clinical outcomes in oesophageal cancer. Eur Radiol. 2014; 24(5):998-1005. DOI: 10.1007/s00330-014-3110-4. View

Blom R, Lagarde S, Klinkenbijl J, Busch O, van Berge Henegouwen M . A high body mass index in esophageal cancer patients does not influence postoperative outcome or long-term survival. Ann Surg Oncol. 2011; 19(3):766-71. PMC: 3278623. DOI: 10.1245/s10434-011-2103-7. View

Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe D, Harris T . Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int. 2009; 21(4):543-59. PMC: 2832869. DOI: 10.1007/s00198-009-1059-y. View

Marcell T . Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci. 2003; 58(10):M911-6. DOI: 10.1093/gerona/58.10.m911. View

Ruiz M, Cefalu C, Reske T . Frailty syndrome in geriatric medicine. Am J Med Sci. 2012; 344(5):395-8. DOI: 10.1097/MAJ.0b013e318256c6aa. View

Peng P, Hyder O, Firoozmand A, Kneuertz P, Schulick R, Huang D . Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma. J Gastrointest Surg. 2012; 16(8):1478-86. PMC: 3578313. DOI: 10.1007/s11605-012-1923-5. View

Sheetz K, Zhao L, Holcombe S, Wang S, Reddy R, Lin J . Decreased core muscle size is associated with worse patient survival following esophagectomy for cancer. Dis Esophagus. 2013; 26(7):716-22. PMC: 4171877. DOI: 10.1111/dote.12020. View

10.

Hasselager R, Gogenur I . Core muscle size assessed by perioperative abdominal CT scan is related to mortality, postoperative complications, and hospitalization after major abdominal surgery: a systematic review. Langenbecks Arch Surg. 2014; 399(3):287-95. DOI: 10.1007/s00423-014-1174-x. View

11.

Prado C, Lieffers J, McCargar L, Reiman T, Sawyer M, Martin L . Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008; 9(7):629-35. DOI: 10.1016/S1470-2045(08)70153-0. View

12.

Awad S, Tan B, Cui H, Bhalla A, Fearon K, Parsons S . Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clin Nutr. 2011; 31(1):74-7. DOI: 10.1016/j.clnu.2011.08.008. View

13.

van Hagen P, Hulshof M, van Lanschot J, Steyerberg E, van Berge Henegouwen M, Wijnhoven B . Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012; 366(22):2074-84. DOI: 10.1056/NEJMoa1112088. View

14.

Dindo D, Demartines N, Clavien P . Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240(2):205-13. PMC: 1360123. DOI: 10.1097/01.sla.0000133083.54934.ae. View

15.

Harimoto N, Shirabe K, Yamashita Y, Ikegami T, Yoshizumi T, Soejima Y . Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 2013; 100(11):1523-30. DOI: 10.1002/bjs.9258. View

16.

Van Vledder M, Levolger S, Ayez N, Verhoef C, Tran T, IJzermans J . Body composition and outcome in patients undergoing resection of colorectal liver metastases. Br J Surg. 2012; 99(4):550-7. DOI: 10.1002/bjs.7823. View

17.

Cosqueric G, Sebag A, Ducolombier C, Thomas C, Piette F, Weill-Engerer S . Sarcopenia is predictive of nosocomial infection in care of the elderly. Br J Nutr. 2006; 96(5):895-901. DOI: 10.1017/bjn20061943. View

18.

Yoshizumi T, Nakamura T, Yamane M, Islam A, Menju M, Yamasaki K . Abdominal fat: standardized technique for measurement at CT. Radiology. 1999; 211(1):283-6. DOI: 10.1148/radiology.211.1.r99ap15283. View

19.

van Meerten E, Muller K, Tilanus H, Siersema P, Eijkenboom W, van Dekken H . Neoadjuvant concurrent chemoradiation with weekly paclitaxel and carboplatin for patients with oesophageal cancer: a phase II study. Br J Cancer. 2006; 94(10):1389-94. PMC: 2361286. DOI: 10.1038/sj.bjc.6603134. View

20.

Buchman A, Wilson R, Bienias J, Bennett D . Change in frailty and risk of death in older persons. Exp Aging Res. 2009; 35(1):61-82. PMC: 2729435. DOI: 10.1080/03610730802545051. View