A Graph Based Framework to Model Virus Integration Sites

Overview

Journal Comput Struct Biotechnol J

Specialty Biotechnology

Date 2016 Jun 4

PMID 27257470

Citations 6

Authors

Raffaele Fronza

Alessandro Vasciaveo

Alfredo Benso

Manfred Schmidt

Affiliations

Soon will be listed here.

Abstract

With next generation sequencing thousands of virus and viral vector integration genome targets are now under investigation to uncover specific integration preferences and to define clusters of integration, termed common integration sites (CIS), that may allow to assess gene therapy safety or to detect disease related genomic features such as oncogenes. Here, we addressed the challenge to: 1) define the notion of CIS on graph models, 2) demonstrate that the structure of CIS enters in the category of scale-free networks and 3) show that our network approach analyzes CIS dynamically in an integrated systems biology framework using the Retroviral Transposon Tagged Cancer Gene Database (RTCGD) as a testing dataset.

Citing Articles

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Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus.

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