Long-term Outcomes of Childhood Onset Nephrotic Syndrome

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2016 Jun 3

PMID 27252935

Citations 15

Authors

Rebecca Hjorten

Zohra Anwar

Kimberly Jean Reidy

Affiliations

Soon will be listed here.

Abstract

There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

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