Steroid Sensitive Nephrotic Syndrome: Revised Guidelines

Overview

Journal Indian Pediatr

Specialty Pediatrics

Date 2021 Mar 20

PMID 33742610

Citations 31

Authors

Aditi Sinha

Arvind Bagga

Sushmita Banerjee

Kirtisudha Mishra

Amarjeet Mehta

Indira Agarwal

Susan Uthup

Abhijeet Saha

Om Prakash Mishra

Affiliations

Soon will be listed here.

Abstract

Justification: Steroid sensitive nephrotic syndrome (SSNS) is one of the most common chronic kidney diseases in children. These guidelines update the existing Indian Society of Pediatric Nephrology recommendations on its management.

Objective: To frame revised guidelines on diagnosis, evaluation, management and supportive care of patients with the illness.

Process: The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by review of literature and evaluation of evidence by experts in two face-to-face meetings.

Recommendations: The initial statements provide advice for evaluation at onset and follow up and indications for kidney biopsy. Subsequent statements provide recommendations for management of the first episode of illness and of disease relapses. Recommendations on the use of immunosuppressive strategies in patients with frequent relapses and steroid dependence are accompanied by suggestions for step-wise approach and plan of monitoring. Guidance is also provided regarding the management of common complications including edema, hypovolemia and serious infections. Advice on immunization and transition of care is given. The revised guideline is intended to improve the management and outcomes of patients with SSNS, and provide directions for future research.

Citing Articles

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Outcomes Using a Standardized Provincial Childhood Nephrotic Syndrome Clinical Pathway.

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Single (375 mg/m) vs. double dose of rituximab along with mycophenolate mofetil for children with steroid-dependent/frequently relapsing nephrotic syndrome: a multicentre open-label randomized controlled trial.

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