Clinical Utility of Speckle-tracking Echocardiography in Cardiac Resynchronisation Therapy

Overview

Journal Echo Res Pract

Date 2016 Jun 2

PMID 27249816

Citations 6

Authors

Sitara G Khan

Dimitris Klettas

Stam Kapetanakis

Mark J Monaghan

Affiliations

Soon will be listed here.

Abstract

Cardiac resynchronisation therapy (CRT) can profoundly improve outcome in selected patients with heart failure; however, response is difficult to predict and can be absent in up to one in three patients. There has been a substantial amount of interest in the echocardiographic assessment of left ventricular dyssynchrony, with the ultimate aim of reliably identifying patients who will respond to CRT. The measurement of myocardial deformation (strain) has conventionally been assessed using tissue Doppler imaging (TDI), which is limited by its angle dependence and ability to measure in a single plane. Two-dimensional speckle-tracking echocardiography is a technique that provides measurements of strain in three planes, by tracking patterns of ultrasound interference ('speckles') in the myocardial wall throughout the cardiac cycle. Since its initial use over 15 years ago, it has emerged as a tool that provides more robust, reproducible and sensitive markers of dyssynchrony than TDI. This article reviews the use of two-dimensional and three-dimensional speckle-tracking echocardiography in the assessment of dyssynchrony, including the identification of echocardiographic parameters that may hold predictive potential for the response to CRT. It also reviews the application of these techniques in guiding optimal LV lead placement pre-implant, with promising results in clinical improvement post-CRT.

Citing Articles

Clinical Utility of Three-Dimensional Speckle-Tracking Echocardiography in Heart Failure.

Gao L, Lin Y, Ji M, Wu W, Li H, Qian M J Clin Med. 2022; 11(21).

PMID: 36362533 PMC: 9656185. DOI: 10.3390/jcm11216307.

Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.

Melki L, Wang D, Grubb C, Weber R, Biviano A, Wan E J Am Soc Echocardiogr. 2021; 34(7):757-766.e8.

PMID: 33675941 PMC: 8263475. DOI: 10.1016/j.echo.2021.02.012.

The Role of Echocardiography in the Optimization of Cardiac Resynchronization Therapy: Current Evidence and Future Perspectives.

Spartalis M, Tzatzaki E, Spartalis E, Damaskos C, Athanasiou A, Livanis E Open Cardiovasc Med J. 2018; 11:133-145.

PMID: 29387277 PMC: 5748829. DOI: 10.2174/1874192401711010133.

Pathophysiology and Current Evidence for Detection of Dyssynchrony.

Spartalis M, Tzatzaki E, Spartalis E, Damaskos C, Athanasiou A, Livanis E Cardiol Res. 2017; 8(5):179-183.

PMID: 29118878 PMC: 5667703. DOI: 10.14740/cr598w.

Echocardiographic Techniques of Deformation Imaging in the Evaluation of Maternal Cardiovascular System in Patients with Complicated Pregnancies.

Visentin S, Palermo C, Camerin M, Daliento L, Muraru D, Cosmi E Biomed Res Int. 2017; 2017:4139635.

PMID: 28904957 PMC: 5585628. DOI: 10.1155/2017/4139635.

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