Novel Window on Early Human Neurodevelopment Via Fetal Exosomes in Maternal Blood

Overview

Journal Ann Clin Transl Neurol

Specialty Neurology

Date 2016 May 28

PMID 27231707

Citations 26

Authors

Laura Goetzl

Nune Darbinian

Edward J Goetzl

Affiliations

Soon will be listed here.

Abstract

Adverse in utero exposures can disrupt fetal brain development, deplete subpopulations of neurons and inhibit formation of normal synaptic connections. A major roadblock to unraveling the precise mechanisms and timing of human neurodevelopmental derangement is the almost complete absence of sensitive noninvasive assessments. We present novel methods for isolating fetal neuronal exosomes from maternal plasma as a noninvasive platform for testing aspects of fetal neurodevelopment as early as the 1st trimester. Our methodology represents an important breakthrough both in understanding mechanisms of injury in vivo in a human system and potentially for monitoring clinical interventions seeking to promote fetal brain health.

Citing Articles

In Utero Alcohol and Tobacco Exposure, Maternal Depression, And Maternal Obesity Are Associated with Impaired Oligodendrocyte Differentiation in The Developing Brain.

Bharai U, Hamze J, Zhang B, Hampe M, Sparks E, Merabova N Obstet Gynecol Res. 2025; 8(1):1-9.

PMID: 40061215 PMC: 11887622. DOI: 10.26502/ogr0172.

Extracellular vesicles and preterm infant diseases.

Chen W, Kongsomros S, Thorman A, Esfandiari L, Morrow A, Chutipongtanate S Front Pediatr. 2025; 13:1550115.

PMID: 40034714 PMC: 11873092. DOI: 10.3389/fped.2025.1550115.

Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury.

Goetzl L, Stephens A, Schlesinger Y, Darbinian N, Merabova N, Hillel M Front Virol. 2025; 1.

PMID: 40012720 PMC: 11864790. DOI: 10.3389/fviro.2021.782863.

Non-Invasive Assessment of Neurogenesis Dysfunction in Fetuses with Early-Onset Growth Restriction Using Fetal Neuronal Exosomes Isolating from Maternal Blood: A Pilot Study.

Gusar V, Kan N, Leonova A, Chagovets V, Tyutyunnik V, Khachatryan Z Int J Mol Sci. 2025; 26(4).

PMID: 40003962 PMC: 11855093. DOI: 10.3390/ijms26041497.

Prenatal Opioid and Alcohol Exposures: Association with Altered Placental Serotonin Transporter Structure and/or Expression.

Darbinian N, Merabova N, Tatevosian G, Adele S, Darbinyan A, Morrison M Int J Mol Sci. 2024; 25(21).

PMID: 39519122 PMC: 11546934. DOI: 10.3390/ijms252111570.

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