Lnc-CC3 Increases Metastasis in Cervical Cancer by Increasing Slug Expression

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 May 26

PMID 27223436

Citations 16

Authors

Binyuan Jiang

Ruili Sun

Shujuan Fang

Changfei Qin

Xi Pan

Li Peng

Yuehui Li

Guancheng Li

Affiliations

Soon will be listed here.

Abstract

Although screening has reduced mortality rates, metastasis still results in poor survival and prognosis in cervical cancer patients. We compared cervical cancer ESTs libraries with other ESTs libraries to identify candidate genes and cloned a novel cervical cancer-associated lncRNA, lnc-CC3. Overexpression of lnc-CC3 promoted migration and invasion by SiHa cervical cancer cells in vitro and in vivo, increased Slug expression, and reduced the expression of the epithelial cell marker E-cadherin. Conversely, lnc-CC3 knockdown altered SiHa cell morphology and increased the expression of E-cadherin, thereby suppressing migration and invasion. These results suggest lnc-CC3 may be a useful marker of metastasis in cervical cancer.

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