MicroRNAs Regulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells (Review)

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2016 May 26

PMID 27222009

Citations 53

Authors

Shuping Peng

Dan Gao

Chengde Gao

Pingpin Wei

Man Niu

Cijun Shuai

Affiliations

Soon will be listed here.

Abstract

Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells (MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro (mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.

Citing Articles

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