Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy Against Primary Cancer Cells

Overview

Journal Theranostics

Date 2016 May 25

PMID 27217839

Citations 20

Authors

Hao Su

Pengcheng Zhang

Andrew G Cheetham

Jin Mo Koo

Ran Lin

Asad Masood

Paula Schiapparelli

Alfredo Quinones-Hinojosa

Honggang Cui

Affiliations

Soon will be listed here.

Abstract

Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy. While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency against cancer cells due to the retarded drug release rate and reduced cellular uptake efficiency. Here we report on the supramolecular design of self-assembling prodrugs (SAPD) with much improved water solubility while maintaining high potency against cancer cells. We found that camptothecin (CPT) prodrugs created by conjugating two CPT molecules onto a hydrophilic segment can associate into filamentous nanostructures in water. Our results suggest that these SAPD exhibit much greater efficacy against primary brain cancer cells relative to that of irinotecan, a clinically used CPT prodrug. We believe these findings open a new avenue for rational design of supramolecular prodrugs for cancer treatment.

Citing Articles

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