Apigenin Inhibits NF-κB and Snail Signaling, EMT and Metastasis in Human Hepatocellular Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 May 21

PMID 27203387

Citations 49

Authors

Yuan Qin

Dong Zhao

Hong-gang Zhou

Xing-Hui Wang

Wei-Long Zhong

Shuang Chen

Wen-Guang Gu

Wei Wang

Chun-Hong Zhang

Yan-Rong Liu

Hui-juan Liu

Qiang Zhang

Yuan-Qiang Guo

Tao Sun

Cheng Yang

Affiliations

Soon will be listed here.

Abstract

Apigenin is a naturally occurring compound with anti-inflammatory, antioxidant, and anticancer properties. In this study, we investigated the effects of apigenin on migration and metastasis in experimental human hepatocellular carcinoma (HCC) cell lines in vitro and in vivo. Apigenin dose-dependently inhibited proliferation, migration, and invasion by PLC and Bel-7402 human HCC cells. It also suppressed tumor growth in PLC cell xenografts without altering body weight, thereby prolonging survival. Apigenin reduced Snai1 and NF-κB expression, reversed increases in epithelial-mesenchymal transition (EMT) marker levels, increased cellular adhesion, regulated actin polymerization and cell migration, and inhibited invasion and migration by HCC cells. Apigenin may therefore inhibit EMT by inhibiting the NF-κB/Snail pathway in human HCC.

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