Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is Not Related to Clinical Classifications

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2016 May 19

PMID 27188849

Citations 1

Authors

Justyna Kiszalkiewicz

Wojciech J Piotrowski

Dorota Pastuszak-Lewandoska

Pawel Gorski

Adam Antczak

Witold Gorski

Daria Domanska-Senderowska

Monika Migdalska-Sek

Karolina H Czarnecka

Ewa Nawrot

Ewa Brzezianska-Lasota

Affiliations

Soon will be listed here.

Abstract

Elevated COX-2 activity is associated with the development of chronic lung diseases leading to bronchial obstruction, including sarcoidosis. The aim of the study was to examine expression pattern of COX-2 messenger RNA (mRNA). Expression was performed by q-PCR method in bronchoalveolar lavage (BAL) cells and peripheral blood (PB) lymphocytes in sarcoidosis patients (n = 61) and control group (n = 30). Analysis of COX-2 mRNA expression level in BAL fluid and PB revealed downregulation in sarcoidosis and control groups. In PB lymphocytes, the statistically significant difference between patients and controls was observed (P = 0.003, Mann-Whitney U test), with higher expression in patients. There were no statistically significant differences between patients without and with parenchymal involvement (stages I vs. II-IV), between patients with acute vs. insidious onset of disease and between patients with abnormal vs. normal spirometry (P > 0.05, Mann-Whitney U test). Results suggest that expression of COX-2 mRNA in patients with pulmonary sarcoidosis is not related to clinical classifications.

Citing Articles

Cigarette smoke extract-mediated FABP4 upregulation suppresses viability and induces apoptosis, inflammation and oxidative stress of bronchial epithelial cells by activating p38 MAPK/MK2 signaling pathway.

Zhang W, Zhang Y, Zhu Q J Inflamm (Lond). 2022; 19(1):7.

PMID: 35706027 PMC: 9202166. DOI: 10.1186/s12950-022-00304-z.

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