Significance of Oncogenes and Tumor Suppressor Genes in AML Prognosis

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 May 16

PMID 27179964

Citations 22

Authors

Maria Kavianpour

Ahmad Ahmadzadeh

Saeid Shahrabi

Najmaldin Saki

Affiliations

Soon will be listed here.

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disorder among hematologic malignancies. Several genetic alterations occur in this disease, which cause proliferative progression, reducing differentiation and apoptosis in leukemic cells as well as increasing their survival. In the genetic study of AML, genetic translocations, gene overexpression, and mutations effective upon biology and pathogenesis of this disease have been recognized. Proto-oncogenes and tumor suppressor genes, which are important in normal development of myeloid cells, are involved in the regulation of cell cycle and apoptosis, undergo mutation in this type of leukemia, and are effective in prognosis of AML subtypes. This review deals with these genes, the assessment of which can be important in the diagnosis and prognosis of patients as well as therapeutic outcome.

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