A Meta-analysis of Platelet Gel for Prevention of Sternal Wound Infections Following Cardiac Surgery

Overview

Journal Blood Transfus

Specialty Hematology

Date 2016 May 14

PMID 27177403

Citations 10

Authors

Bilal H Kirmani

Sion G Jones

Subir Datta

Edward K Mclaughlin

Andreas J Hoschtitzky

Affiliations

Soon will be listed here.

Abstract

Deep sternal wound infection and bleeding are devastating complications following cardiac surgery, which may be reduced by topical application of autologous platelet gel. Systematic review identified seven comparative studies involving 4,692 patients. Meta-analysis showed significant reductions in all sternal wound infections (odds ratio 3.48 [1.08-11.23], p=0.04) and mediastinitis (odds ratio 2.69 [1.20-6.06], p=0.02) but not bleeding. No adverse events relating to the use of topical platelet-rich plasma were reported. The use of autologous platelet gel in cardiac surgery appears to provide significant reductions in serious sternal wound infections, and its use is unlikely to be associated with significant risk.

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