Prognostic Value of MicroRNAs in Cervical Carcinoma: a Systematic Review and Meta-analysis

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 May 14

PMID 27177085

Citations 14

Authors

Shengkang Dai

Yan Lu

Ying Long

Yuehua Lai

Ping Du

Nan Ding

Desheng Yao

Affiliations

Soon will be listed here.

Abstract

This systematic review is written to investigate the outcome of cervical cancer. A comprehensive search of PubMed and EMBASE was performed to identify eligible studies. Nineteen studies from thirteen articles with a total of 1,310 participants were included in this meta-analysis. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) as a prognosis for cervical cancer were extracted and calculated, if available. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using STATA (version 12.0), resulting in the pooled HRs 0.70 (95% CI: 0.51-0.97) for OS, 1.02 (95% CI: 0.53-1.98) for DFS, and 0.56 (95% CI: 0.40-0.77) for RFS. The results indicated that cervical cancer patients with decreased microRNA expression were associated with shorter OS and RFS. It suggested that microRNAs might be promising markers for predicting the survival rate of cervical cancer.

Citing Articles

The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and -analysis.

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The diagnostic accuracy of serum microRNAs in detection of cervical cancer: a systematic review protocol.

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Role of microRNAs in Predicting the Prognosis of Cervical Cancer Cases: A Systematic Review and Meta-Analysis.

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MiRNAs: A Powerful Tool in Deciphering Gynecological Malignancies.

Duica F, Condrat C, Danila C, Boboc A, Radu M, Xiao J Front Oncol. 2020; 10:591181.

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Proteomic analysis of human cervical adenocarcinoma mucus to identify potential protein biomarkers.

Ma Z, Chen J, Luan T, Chu C, Wu W, Zhu Y PeerJ. 2020; 8:e9527.

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