Polymorphisms in MiRNA Genes Play Roles in the Initiation and Development of Cervical Cancer

Overview

Journal J Cancer

Specialty Oncology

Date 2019 Oct 11

PMID 31598146

Citations 11

Authors

Zhiling Yan

Ziyun Zhou

Chuanyin Li

Xielang Yang

Longyu Yang

Shuying Dai

Jiehan Zhao

Huijing Ni

Li Shi

YuFeng Yao

Affiliations

Soon will be listed here.

Abstract

MicroRNA deregulation is crucial for cancer development. Studies showed that polymorphisms in miRNA genes could affect miRNA expression, which might be associated with cancer development. In the current study, we investigated the association of seven single nucleotide polymorphisms (SNPs) in seven miRNA genes with the initiation and development of cervical cancer in a Chinese Han population. The SNPs of 358 cervical intraepithelial neoplasia (CIN) patients, 547 cervical cancer patients and 567 healthy individuals were genotyped using TaqMan assays. Moreover, we evaluated the association of the seven SNPs with the different stages of cervical cancer. Our results showed that rs4636297 in miR-126 was associated with susceptibility to CIN and cervical cancer (=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (=1.334, : 1.049-1.698) and cervical cancer (=1.296, : 1.044-1.609). Similarly, rs11614913 in miR-125a was associated with CIN and cervical cancer (=0.025 and 0.015, respectively), and the T allele might be the protective factor for CIN (=0.807, : 0.669-0.974) and cervical cancer (=0.814, : 0.689-0.961). Our results indicated that rs4636297 in miR-126 and rs11614913 in miR-196a2 play an important role only in the initiation of cervical cancer not in the development of CIN to cervical cancer.

Citing Articles

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References

Jia Z, Cao D, Wu Y, Jin M, Pan Y, Cao X . Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer. World J Gastroenterol. 2019; 25(8):1012-1023. PMC: 6397727. DOI: 10.3748/wjg.v25.i8.1012. View

Ayremlou N, Mozdarani H, Mowla S, Delavari A . Increased levels of serum and tissue miR-107 in human gastric cancer: Correlation with tumor hypoxia. Cancer Biomark. 2015; 15(6):851-60. DOI: 10.3233/CBM-150529. View

Guo Z, Maki M, Ding R, Yang Y, Zhang B, Xiong L . Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci Rep. 2014; 4:5150. PMC: 5381490. DOI: 10.1038/srep05150. View

Saito Y, Friedman J, Chihara Y, Egger G, Chuang J, Liang G . Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun. 2009; 379(3):726-31. DOI: 10.1016/j.bbrc.2008.12.098. View

Wu Y, Xu Q, He C, Li Y, Liu J, Deng N . Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer. Sci Rep. 2017; 7:39528. PMC: 5220333. DOI: 10.1038/srep39528. View

Munoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith J . Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet. 2002; 359(9312):1093-101. DOI: 10.1016/S0140-6736(02)08151-5. View

Wang S, Cao X, Ding B, Chen J, Cui M, Xu Y . The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population. Gene. 2016; 595(1):109-114. DOI: 10.1016/j.gene.2016.10.002. View

Qi P, Wang L, Zhou B, Yao W, Xu S, Zhou Y . Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population. Genet Mol Res. 2015; 14(2):6289-96. DOI: 10.4238/2015.June.11.2. View

Cho W, Chow A, Au J . Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer. 2009; 45(12):2197-206. DOI: 10.1016/j.ejca.2009.04.039. View

10.

Zhang J, Wang C, Hua L, Yao K, Chen J, Hu J . miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2. Int J Clin Exp Pathol. 2015; 8(5):5168-74. PMC: 4503085. View

11.

Feng R, Chen X, Yu Y, Su L, Yu B, Li J . miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett. 2010; 298(1):50-63. DOI: 10.1016/j.canlet.2010.06.004. View

12.

Moscicki A, Widdice L, Ma Y, Farhat S, Miller-Benningfield S, Jonte J . Comparison of natural histories of human papillomavirus detected by clinician- and self-sampling. Int J Cancer. 2010; 127(8):1882-92. PMC: 3132413. DOI: 10.1002/ijc.25199. View

13.

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M . Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006; 9(3):189-98. DOI: 10.1016/j.ccr.2006.01.025. View

14.

Xu Q, Wu Y, Li Y, He C, Sun L, Liu J . SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese population. Oncotarget. 2016; 7(17):23700-14. PMC: 5029657. DOI: 10.18632/oncotarget.8057. View

15.

Yang R, Dick M, Marme F, Schneeweiss A, Langheinz A, Hemminki K . Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Res Treat. 2010; 127(2):549-54. DOI: 10.1007/s10549-010-1244-x. View

16.

Wang Y, Hu H, Weng H, Chen H, Luo C, Ji J . Association between Polymorphisms in MicroRNAs and Risk of Urological Cancer: A Meta-Analysis Based on 17,019 Subjects. Front Physiol. 2017; 8:325. PMC: 5437731. DOI: 10.3389/fphys.2017.00325. View

17.

Torruella-Loran I, Laayouni H, Dobon B, Gallego A, Balcells I, Garcia-Ramallo E . MicroRNA Genetic Variation: From Population Analysis to Functional Implications of Three Allele Variants Associated with Cancer. Hum Mutat. 2016; 37(10):1060-73. DOI: 10.1002/humu.23045. View

18.

Feng S, Wang L, Liu W, Zhong Y, Xu S . MiR-126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis. J Clin Lab Anal. 2018; 32(9):e22588. PMC: 6816918. DOI: 10.1002/jcla.22588. View

19.

Wang Q, Zhu Y, Zhang H, Xiao J . Altered MiRNA expression in gastric cancer: a systematic review and meta-analysis. Cell Physiol Biochem. 2015; 35(3):933-44. DOI: 10.1159/000369750. View

20.

Shin K, Jung D, Hong M, Kang H, Lee W, Yoo S . The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer. Gene. 2015; 577(2):148-52. DOI: 10.1016/j.gene.2015.11.036. View