Molecular Networks Underlying Myofibroblast Fate and Fibrosis

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2016 May 12

PMID 27167848

Citations 82

Authors

April Stempien-Otero

Deok-Ho Kim

Jennifer Davis

Affiliations

Soon will be listed here.

Abstract

Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart's fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor cell populations, and the core signaling network that orchestrates myofibroblast differentiation as a way of understanding the basic determinants of fibrotic disease in the heart and other tissues.

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