Circulating MiR-499 As a Potential Biomarker for Acute Myocardial Infarction

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2016 May 11

PMID 27162785

Citations 28

Authors

Yunyi Xin

Chengjian Yang

Zhijun Han

Affiliations

Soon will be listed here.

Abstract

Acute myocardial infarction (AMI), a common heart disease that may lead to chronic heart failure, is the leading cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) are small non-coding RNAs that mediate the expression of target genes. Recently, a number of miRNAs are emerging as potential biomarkers of AMI. MiRNA-499 is a newly discovered member of miRNAs, and is mainly expressed in myocardium, the circulating levels of miRNA-499 was increased in AMI patients. This review summarizes the latest advances in the miRNA-499 study and discusses the potential of miRNA-499 to be a biomarker of AMI.

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