The Landscape of DNA Methylation Amid a Perfect Storm of Autism Aetiologies

Overview

Journal Nat Rev Neurosci

Specialty Neurology

Date 2016 May 7

PMID 27150399

Citations 85

Authors

Annie Vogel Ciernia

Janine LaSalle

Affiliations

Soon will be listed here.

Abstract

Increasing evidence points to a complex interplay between genes and the environment in autism spectrum disorder (ASD), including rare de novo mutations in chromatin genes such as methyl-CpG binding protein 2 (MECP2) in Rett syndrome. Epigenetic mechanisms such as DNA methylation act at this interface, reflecting the plasticity in metabolic and neurodevelopmentally regulated gene pathways. Genome-wide studies of gene sequences, gene pathways and DNA methylation are providing valuable mechanistic insights into ASD. The dynamic developmental landscape of DNA methylation is vulnerable to numerous genetic and environmental insults: therefore, understanding pathways that are central to this 'perfect storm' will be crucial to improving the diagnosis and treatment of ASD.

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