Mechanics of Epithelial Tissues During Gap Closure

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2016 May 1

PMID 27131272

Citations 57

Authors

Simon Begnaud

Tianchi Chen

Delphine Delacour

Rene-Marc Mege

Benoit Ladoux

Affiliations

Soon will be listed here.

Abstract

The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based contractile cables and/or protrusive activity of cells lining the gap. This review discusses the relative contributions of 'purse-string' and cell crawling mechanisms regulated by cell-substrate and cell-cell interactions, cellular mechanics and physical constraints from the environment.

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