Interaction Between Muscle and Bone, and Improving the Effects of Electrical Muscle Stimulation on Amyotrophy and Bone Loss in a Denervation Rat Model Via Sciatic Neurectomy

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2016 Apr 29

PMID 27123252

Citations 7

Authors

B O Feng

Wei Wu

Hua Wang

Junchen Wang

Dongya Huang

Ling Cheng

Affiliations

Soon will be listed here.

Abstract

The side-to-side difference in bone mineral content and soft tissue composition of extremities and their associations have been observed in patients with stroke and the results are inconsistent. The aim of the present study was to investigate the interaction between bone mineral content (BMC), lean mass (LM) and fat mass (FM) in the paretic extremities in patients following stroke and to determine the effectiveness of electrical muscle stimulation (EMS) following sciatic neurectomy (SN) in rats. BMC, LM and FM were measured by dual-energy X-ray absorptiometry in 61 hemiplegic patients following stroke. In the rat model study, groups of 10 Sprague-Dawley rats were divided into EMS and non-EMS subgroups. Myostatin expression and tetracycline interlabel width were measured. There were significant decreases in BMC, LM and FM in paretic limbs compared to non-paretic limbs. Compared to non-EMS, downregulated myostatin mRNA, and upregulated mechano growth factor (MGF) and insulin-like growth factor 1 (IGF-1) mRNA expression levels were observed in the EMS subgroup (P<0.05). In conclusion, muscle may have an important role in maintaining BMC. EMS-induced muscle contraction effectively downregulated myostatin mRNA, upregulated MGF and IGF-1 mRNA expression in muscle fiber, and mitigated amyotrophy and cortical bone loss from SN.

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References

Elkasrawy M, Hamrick M . Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010; 10(1):56-63. PMC: 3753581. View

Hill M, Goldspink G . Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol. 2003; 549(Pt 2):409-18. PMC: 2342958. DOI: 10.1113/jphysiol.2002.035832. View

Roth S, Martel G, Ferrell R, Metter E, Hurley B, Rogers M . Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood). 2003; 228(6):706-9. DOI: 10.1177/153537020322800609. View

Iwamoto J, Takeda T, Ichimura S . Relationships between physical activity and metacarpal cortical bone mass and bone resorption in hemiplegic patients. J Orthop Sci. 2001; 6(3):227-33. DOI: 10.1007/s007760100039. View

Riddoch-Contreras J, Yang S, Dick J, Goldspink G, Orrell R, Greensmith L . Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Exp Neurol. 2008; 215(2):281-9. DOI: 10.1016/j.expneurol.2008.10.014. View

Nielsen S, Pedersen B . Skeletal muscle as an immunogenic organ. Curr Opin Pharmacol. 2008; 8(3):346-51. DOI: 10.1016/j.coph.2008.02.005. View

Pang M, Eng J . Muscle strength is a determinant of bone mineral content in the hemiparetic upper extremity: implications for stroke rehabilitation. Bone. 2005; 37(1):103-11. PMC: 3167823. DOI: 10.1016/j.bone.2005.03.009. View

Sahin L, Ozoran K, Gunduz O, Ucan H, Yucel M . Bone mineral density in patients with stroke. Am J Phys Med Rehabil. 2001; 80(8):592-6. DOI: 10.1097/00002060-200108000-00009. View

Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N . Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab. 2003; 285(2):E363-71. DOI: 10.1152/ajpendo.00487.2002. View

10.

Bamman M, Shipp J, Jiang J, Gower B, Hunter G, Goodman A . Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinol Metab. 2001; 280(3):E383-90. DOI: 10.1152/ajpendo.2001.280.3.E383. View

11.

West C, Arnett T, Farrow S . Expression of insulin-like growth factor I (IGF-I) mRNA variants in rat bone. Bone. 1996; 19(1):41-6. DOI: 10.1016/8756-3282(96)00105-6. View

12.

Engler D . Hypothesis: Musculin is a hormone secreted by skeletal muscle, the body's largest endocrine organ. Evidence for actions on the endocrine pancreas to restrain the beta-cell mass and to inhibit insulin secretion and on the hypothalamus to co-ordinate.... Acta Biomed. 2007; 78 Suppl 1:156-206. View

13.

Hameed M, Orrell R, Cobbold M, Goldspink G, Harridge S . Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol. 2003; 547(Pt 1):247-54. PMC: 2342624. DOI: 10.1113/jphysiol.2002.032136. View

14.

Wei C, Ohira , Tanaka T, Yonemitsu H, Ueda A . Does electrical stimulation of the sciatic nerve prevent suspension-induced changes in rat hindlimb bones?. Jpn J Physiol. 1998; 48(1):33-7. DOI: 10.2170/jjphysiol.48.33. View

15.

Hamrick M, Samaddar T, Pennington C, McCormick J . Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise. J Bone Miner Res. 2006; 21(3):477-83. DOI: 10.1359/JBMR.051203. View

16.

Owino V, Yang S, Goldspink G . Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload. FEBS Lett. 2001; 505(2):259-63. DOI: 10.1016/s0014-5793(01)02825-3. View