Nutmeg Oil Alleviates Chronic Inflammatory Pain Through Inhibition of COX-2 Expression and Substance P Release in Vivo

Overview

Journal Food Nutr Res

Specialty Nutritional Sciences

Date 2016 Apr 29

PMID 27121041

Citations 17

Authors

Wei Kevin Zhang

Shan-Shan Tao

Ting-Ting Li

Yu-Sang Li

Xiao-Jun Li

He-Bin Tang

Ren-Huai Cong

Fang-Li Ma

Chu-Jun Wan

Affiliations

Soon will be listed here.

Abstract

Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain.

Methods And Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree.

Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

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