CGMP-Dependent Protein Kinase Encoded by Foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Apr 22

PMID 27098704

Citations 10

Authors

Qionglin Peng

Yijin Wang

Meixia Li

Deliang Yuan

Mengbo Xu

Changqing Li

Zhefeng Gong

Renjie Jiao

Li Liu

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Axon pathfinding and target recognition are important processes in the formation of specific neuronal connectivity, which rely upon precise coordinated deployment of multiple guidance factors. This paper reveals the role of cGMP-dependent protein kinase (PKG) in regulating the pathfinding and targeting of the developing axons in Drosophila Moreover, our study indicates that PKG regulates the cytoplasmic-nuclear trafficking of the transcription factor LolaT, suggesting a mechanism of PKG in directing motor axon guidance. These findings highlight a new function of PKG in axon guidance by suppressing a transcription factor.

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