Evaluating the Effects of Vitamin D and Vitamin E Supplement on Premenstrual Syndrome: A Randomized, Double-blind, Controlled Trial

Overview

Journal Iran J Nurs Midwifery Res

Specialty Nursing

Date 2016 Apr 21

PMID 27095989

Citations 8

Authors

Hajar Dadkhah

Elham Ebrahimi

Nahid Fathizadeh

Affiliations

Soon will be listed here.

Abstract

Background: Premenstrual syndrome (PMS) can cause problems in daily work and relationships.

Materials And Methods: Eighty-six women were randomly assigned to two intervention groups and one control group. Patients were asked to fill out the PMS Daily Symptoms Record for 2 months, and then the participants were randomly assigned to one of the three study groups. Medical intervention was carried out for 2 months with the participants in each group receiving either a tablet containing 200 mg vitamin D, 100 mg vitamin E, or a placebo each day, respectively. After 2 months, the results of pre- and post-intervention were compared. P < 0.005 was considered significant.

Results: After the intervention, the mean score of the syndrome significantly decreased in all the three groups (12, 16, and 8 participants had decreased scores in vitamin D, vitamin E, and placebo, respectively). The differences between groups were not significant (P > 0.05).

Conclusions: Supplemental therapy with vitamins D and E is an effective and affordable treatment for PMS.

Citing Articles

Relationships between Premenstrual Syndrome (PMS) and Diet Composition, Dietary Patterns and Eating Behaviors.

Oboza P, Ogarek N, Wojtowicz M, Rhaiem T, Olszanecka-Glinianowicz M, Kocelak P Nutrients. 2024; 16(12).

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Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trials.

Robinson J, Ferreira A, Iacovou M, Kellow N Nutr Rev. 2024; 83(2):280-306.

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Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology.

Calcaterra V, Nappi R, Farolfi A, Tiranini L, Rossi V, Regalbuto C Children (Basel). 2022; 9(2).

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Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies.

Granda D, Szmidt M, Kaluza J Antioxidants (Basel). 2021; 10(4).

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Effect of zinc supplementation on quality of life and sleep quality in young women with premenstrual syndrome: a randomized, double-blind, placebo-controlled trial.

Jafari F, Tarrahi M, Farhang A, Amani R Arch Gynecol Obstet. 2020; 302(3):657-664.

PMID: 32514756 DOI: 10.1007/s00404-020-05628-w.

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