Interferon-induced Guanylate-binding Proteins in Inflammasome Activation and Host Defense

Overview

Journal Nat Immunol

Date 2016 Apr 20

PMID 27092805

Citations 86

Authors

Bae-Hoon Kim

Jonathan D Chee

Clinton J Bradfield

Eui-Soon Park

Pradeep Kumar

John D MacMicking

Affiliations

Soon will be listed here.

Abstract

Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype-specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases.

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