Lung Bioaccessibility of Contaminants in Particulate Matter of Geological Origin

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2016 Apr 16

PMID 27080406

Citations 5

Authors

Mert Guney

Robert P Chapuis

Gerald J Zagury

Affiliations

Soon will be listed here.

Abstract

Human exposure to particulate matter (PM) has been associated with adverse health effects. While inhalation exposure to airborne PM is a prominent research subject, exposure to PM of geological origin (i.e., generated from soil/soil-like material) has received less attention. This review discusses the contaminants in PM of geological origin and their relevance for human exposure and then evaluates lung bioaccessibility assessment methods and their use. PM of geological origin can contain toxic elements as well as organic contaminants. Observed/predicted PM lung clearance times are long, which may lead to prolonged contact with lung environment. Thus, certain exposure scenarios warrant the use of in vitro bioaccessibility testing to predict lung bioavailability. Limited research is available on lung bioaccessibility test development and test application to PM of geological origin. For in vitro tests, test parameter variation between different studies and concerns about physiological relevance indicate a crucial need for test method standardization and comparison with relevant animal data. Research is recommended on (1) developing robust in vitro lung bioaccessibility methods, (2) assessing bioaccessibility of various contaminants (especially polycyclic aromatic hydrocarbons (PAHs)) in PM of diverse origin (surface soils, mine tailings, etc.), and (3) risk characterization to determine relative importance of exposure to PM of geological origin.

Citing Articles

Characterization of the inhalable fraction (< 10 μm) of soil from highly urbanized and industrial environments: magnetic measurements, bioaccessibility, Pb isotopes and health risk assessment.

Menegaki S, Kelepertzis E, Kypritidou Z, Lampropoulou A, Chrastny V, Aidona E Environ Geochem Health. 2024; 46(7):230.

PMID: 38849623 PMC: 11161548. DOI: 10.1007/s10653-024-02009-z.

Enhanced Gastric/Lung Arsenic Bioaccessibility from Lignite Fly Ashes: Comparing Bioaccessibility Rates with Multiple Environmental Matrices.

Bourliva A, Kelepertzis E, Papadopoulou L, Patinha C, Kantiranis N Toxics. 2023; 11(4).

PMID: 37112585 PMC: 10143711. DOI: 10.3390/toxics11040358.

Bioaccessibility of potentially toxic elements in mine residue particles.

Jesus Eulises C, Gonzalez-Chavez M, Carrillo-Gonzalez R, Garcia-Cue J, Fernandez-Reynoso D, Noerpel M Environ Sci Process Impacts. 2021; 23(2):367-380.

PMID: 33527965 PMC: 8935130. DOI: 10.1039/d0em00447b.

The influence that different urban development models has on PM elemental and bioaccessible profiles.

Polezer G, Oliveira A, Potgieter-Vermaak S, Godoi A, de Souza R, Yamamoto C Sci Rep. 2019; 9(1):14846.

PMID: 31619713 PMC: 6795900. DOI: 10.1038/s41598-019-51340-4.

Metal concentrations in homing pigeon lung tissue as a biomonitor of atmospheric pollution.

Cui J, Halbrook R, Zang S, Han S, Li X Ecotoxicology. 2017; 27(2):169-174.

PMID: 29273855 DOI: 10.1007/s10646-017-1882-4.

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