HIV-1 Gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological Disorders

Overview

Journal Neurotox Res

Publisher Springer

Specialty Neurology

Date 2016 Apr 14

PMID 27072361

Citations 10

Authors

Ankit Shah

Anil Kumar

Affiliations

Soon will be listed here.

Abstract

The treatment of HIV infection presents a great challenge among the patients who develop various forms of cognitive impairments. Particularly, the neurotoxicity associated with HIV is attributed to different viral proteins present in HIV, and is a root cause for HIV-associated neurocognitive disorders (HAND). A common characteristic among several neurodegenerative disorders including HAND is mitochondrial dysfunction in various brain cells. However, there has been very little effort to explore the possibility of exploiting mitochondrial dynamics in HAND treatment. A recent study by Avdoshina and colleagues has reported the role of mitochondrial dysfunction in HIV-1 gp120-mediated neuronal dysfunction, which presents a novel mechanism for the development of adjunct therapy to treat HAND.

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