Insulin-like Growth Factors and Their Potential Role in Cardiac Epigenetics

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2016 Apr 11

PMID 27061217

Citations 3

Authors

Cristiana Iosef Husted

Maria Valencik

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) constitutes a major public health threat worldwide, accounting for 17.3 million deaths annually. Heart disease and stroke account for the majority of healthcare costs in the developed world. While much has been accomplished in understanding the pathophysiology, molecular biology and genetics underlying the diagnosis and treatment of CVD, we know less about the role of epigenetics and their molecular determinants. The impact of environmental changes and epigenetics in CVD is now emerging as critically important in understanding the origin of disease and the development of new therapeutic approaches to prevention and treatment. This review focuses on the emerging role of epigenetics mediated by insulin like-growth factors-I and -II in major CVDs such as heart failure, cardiac hypertrophy and diabetes.

Citing Articles

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Insulin-Like Growth Factor-II and Ischemic Stroke-A Prospective Observational Study.

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References

Connelly J, Cherepanova O, Doss J, Karaoli T, Lillard T, Markunas C . Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. Hum Mol Genet. 2013; 22(25):5107-20. PMC: 3842173. DOI: 10.1093/hmg/ddt365. View

Kashyap V, Rezende N, Scotland K, Shaffer S, Persson J, Gudas L . Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev. 2009; 18(7):1093-108. PMC: 3135180. DOI: 10.1089/scd.2009.0113. View

Katoh M . Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review). Int J Mol Med. 2013; 32(4):763-7. PMC: 3812243. DOI: 10.3892/ijmm.2013.1444. View

Grossniklaus U, Kelly W, Kelly B, Ferguson-Smith A, Pembrey M, Lindquist S . Transgenerational epigenetic inheritance: how important is it?. Nat Rev Genet. 2013; 14(3):228-35. PMC: 4066847. DOI: 10.1038/nrg3435. View

Ulaner G, Yang Y, Hu J, Li T, Vu T, Hoffman A . CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues. Endocrinology. 2003; 144(10):4420-6. DOI: 10.1210/en.2003-0681. View

Cortessis V, Thomas D, Levine A, Breton C, Mack T, Siegmund K . Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012; 131(10):1565-89. PMC: 3432200. DOI: 10.1007/s00439-012-1189-8. View

Heijmans B, Tobi E, Stein A, Putter H, Blauw G, Susser E . Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008; 105(44):17046-9. PMC: 2579375. DOI: 10.1073/pnas.0806560105. View

Napoli C, de Nigris F, Welch J, Calara F, Stuart R, Glass C . Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation. 2002; 105(11):1360-7. DOI: 10.1161/hc1102.106792. View

Cohen G, Jeffery H, Lagercrantz H, Katz-Salamon M . Long-term reprogramming of cardiovascular function in infants of active smokers. Hypertension. 2010; 55(3):722-8. DOI: 10.1161/HYPERTENSIONAHA.109.142695. View

10.

Miranda T, Jones P . DNA methylation: the nuts and bolts of repression. J Cell Physiol. 2007; 213(2):384-90. DOI: 10.1002/jcp.21224. View

11.

Shan Z, Lin Q, Deng C, Zhu J, Mai L, Liu J . miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes. FEBS Lett. 2010; 584(16):3592-600. DOI: 10.1016/j.febslet.2010.07.027. View

12.

Hiltunen M, Turunen M, Hakkinen T, Rutanen J, Hedman M, Makinen K . DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med. 2002; 7(1):5-11. DOI: 10.1191/1358863x02vm418oa. View

13.

Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera M . The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013; 27(23):2543-8. PMC: 3861668. DOI: 10.1101/gad.224170.113. View

14.

Cash H, McGarvey S, Houseman E, Marsit C, Hawley N, Lambert-Messerlian G . Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics. 2011; 6(10):1257-64. PMC: 3225843. DOI: 10.4161/epi.6.10.17728. View

15.

Baccarelli A, Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L . Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology. 2010; 21(6):819-28. PMC: 3690659. DOI: 10.1097/EDE.0b013e3181f20457. View

16.

Meigs J, Jacques P, Selhub J, Singer D, Nathan D, Rifai N . Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care. 2001; 24(8):1403-10. DOI: 10.2337/diacare.24.8.1403. View

17.

Chang K, Chan-Ling T, McFarland E, Afzal A, Pan H, Baxter L . IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A. 2007; 104(25):10595-600. PMC: 1965558. DOI: 10.1073/pnas.0702072104. View

18.

Baccarelli A, Rienstra M, Benjamin E . Cardiovascular epigenetics: basic concepts and results from animal and human studies. Circ Cardiovasc Genet. 2010; 3(6):567-73. PMC: 3030456. DOI: 10.1161/CIRCGENETICS.110.958744. View

19.

Handy D, Castro R, Loscalzo J . Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011; 123(19):2145-56. PMC: 3107542. DOI: 10.1161/CIRCULATIONAHA.110.956839. View

20.

Bouchard L, Hivert M, Guay S, St-Pierre J, Perron P, Brisson D . Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration. Diabetes. 2012; 61(5):1272-80. PMC: 3331769. DOI: 10.2337/db11-1160. View