Relaxation Properties of Human Umbilical Cord Blood at 1.5 Tesla

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2016 Apr 10

PMID 27059881

Citations 21

Authors

Sharon Portnoy

Mark Osmond

Meng Yuan Zhu

Mike Seed

John G Sled

Christopher K Macgowan

Affiliations

Soon will be listed here.

Abstract

Purpose: To characterize the MRI relaxation properties of human umbilical cord blood at 1.5 Tesla.

Methods: Relaxometry measurements were performed on cord blood specimens (N = 88, derived from six caesarean deliveries) spanning a broad range of hematocrits (Hct = 0.19-0.76) and oxygen saturations (sO = 4-100%), to characterize the dependence of T and T on these blood properties. Adult blood data (N = 31 specimens, derived from two volunteers) were similarly studied to validate our experimental methods by comparison with existing literature. Using biophysical models previously developed for adult blood, new model parameters were estimated, which relate Hct and sO to the observed cord blood relaxation times.

Results: Fitted biophysical models explained more than 90% of the variation in T and T . In general, T relaxation times of cord blood were longer (by up to 35%) than those of adult blood, whereas T relaxation times were slightly shorter (by up to 10%).

Conclusions: The models and fitted parameters presented here can be used for calibration of future MRI investigations of fetal and neonatal blood physiology. This study is an important step in facilitating accurate, noninvasive assessments of fetal blood oxygen content, a valuable diagnostic parameter in the identification and treatment of fetal hypoxia. Magn Reson Med 77:1678-1690, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Citing Articles

Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease.

Sadiku E, Sun L, Macgowan C, Seed M, Morrison J Front Cardiovasc Med. 2024; 11:1426593.

PMID: 39108671 PMC: 11300254. DOI: 10.3389/fcvm.2024.1426593.

Acute-on-chronic: using magnetic resonance imaging to disentangle the haemodynamic responses to acute and chronic fetal hypoxaemia.

Darby J, Saini B, Holman S, Hammond S, Perumal S, Macgowan C Front Med (Lausanne). 2024; 11:1340012.

PMID: 38933113 PMC: 11199546. DOI: 10.3389/fmed.2024.1340012.

Oxygen saturation-dependent effects on blood transverse relaxation at low fields.

Thomas D, Galvosas P, Tzeng Y, Harrison F, Berry M, Teal P MAGMA. 2022; 35(5):805-815.

PMID: 35107697 PMC: 9463268. DOI: 10.1007/s10334-021-00993-2.

Quantitative T and T mapping by magnetic resonance fingerprinting (MRF) of the placenta before and after maternal hyperoxia.

Stout J, Liao C, Gagoski B, Abaci Turk E, Feldman H, Bibbo C Placenta. 2021; 114:124-132.

PMID: 34537569 PMC: 8511125. DOI: 10.1016/j.placenta.2021.08.058.

Magnetic resonance imaging of placentome development in the pregnant Ewe.

Flouri D, Darby J, Holman S, Perumal S, David A, Morrison J Placenta. 2021; 105:61-69.

PMID: 33549925 PMC: 7611430. DOI: 10.1016/j.placenta.2021.01.017.

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