Multiple Functions of the Histone Chaperone Jun Dimerization Protein 2

Overview

Journal Gene

Specialty Molecular Biology

Date 2016 Apr 5

PMID 27041241

Citations 14

Authors

Ming-Ho Tsai

Kenly Wuputra

Yin-Chu Lin

Chang-Shen Lin

Kazunari K Yokoyama

Affiliations

Soon will be listed here.

Abstract

The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element. It also plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor. However, the molecular mechanisms underlying these multiple functions of JDP2 have not been clarified. This review summarizes the structure and function of JDP2, highlighting the specific role of JDP2 in cellular-stress regulation and prevention.

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