[Caspase-1 Regulates Autoinflammation in Rheumatic Diseases]

Overview

Journal Z Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2016 Apr 2

PMID 27034076

Citations 6

Authors

S Winkler

C M Hedrich

A Rosen-Wolff

Affiliations

Soon will be listed here.

Abstract

Caspase-1 is an integral regulator of the innate immune system. Its core functions are the processing and secretion of the proinflammatory cytokines interleukin 1β (IL-1 beta) and IL-18 and the initiation of proinflammatory cell death, which is referred to as pyroptosis. Activation of caspase-1 plays a pivotal role during immune defense mechanisms against infections by the innate immune system. Dysregulated activation of caspase-1 has been recognized to be involved in the pathophysiology of a constantly increasing number of inflammatory diseases. This article gives an overview of the regulation and function of caspase-1 and its involvement in monogenic, polygenic and/or polyetiological rheumatic diseases.

Citing Articles

An improved understanding of pediatric chronic nonbacterial osteomyelitis pathophysiology informs current and future treatment.

Roberts E, Charras A, Hahn G, Hedrich C J Bone Miner Res. 2024; 39(11):1523-1538.

PMID: 39209330 PMC: 11523093. DOI: 10.1093/jbmr/zjae141.

Optimization of Sperm Cryopreservation Formulation in .

Chang L, Lu C, Zhu J, Chen Y, Wang C, Mu C Int J Mol Sci. 2023; 24(5).

PMID: 36901789 PMC: 10001725. DOI: 10.3390/ijms24054358.

Vasculitis in Cystic Fibrosis.

Sposito F, McNamara P, Hedrich C Front Pediatr. 2020; 8:585275.

PMID: 33282799 PMC: 7690646. DOI: 10.3389/fped.2020.585275.

Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury.

Zhu J, Fu Y, Tu G Exp Ther Med. 2020; 20(2):1675-1681.

PMID: 32742397 PMC: 7388327. DOI: 10.3892/etm.2020.8832.

Expression of Caspase-1 in breast cancer tissues and its effects on cell proliferation, apoptosis and invasion.

Sun Y, Guo Y Oncol Lett. 2018; 15(5):6431-6435.

PMID: 29725399 PMC: 5920210. DOI: 10.3892/ol.2018.8176.

References

Fife M, Gutierrez A, Ogilvie E, Stock C, Samuel J, Thomson W . Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res Ther. 2006; 8(5):R148. PMC: 1779449. DOI: 10.1186/ar2041. View

Cavalli G, Dinarello C . Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatology (Oxford). 2015; 54(12):2134-44. PMC: 5009422. DOI: 10.1093/rheumatology/kev269. View

Canna S, de Jesus A, Gouni S, Brooks S, Marrero B, Liu Y . An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet. 2014; 46(10):1140-6. PMC: 4177369. DOI: 10.1038/ng.3089. View

Beukelman T, Guevara J, Albert D . Optimal treatment of knee monarthritis in juvenile idiopathic arthritis: a decision analysis. Arthritis Rheum. 2008; 59(11):1580-8. DOI: 10.1002/art.24190. View

Bruck N, Schnabel A, Hedrich C . Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches. Clin Immunol. 2015; 159(1):72-83. DOI: 10.1016/j.clim.2015.04.018. View

Hedrich C, Fiebig B, Sallmann S, Bruck N, Hahn G, Roesler J . Good response to IL-1beta blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies. Scand J Rheumatol. 2008; 37(5):385-9. DOI: 10.1080/03009740801978889. View

Miao E, Mao D, Yudkovsky N, Bonneau R, Lorang C, Warren S . Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A. 2010; 107(7):3076-80. PMC: 2840275. DOI: 10.1073/pnas.0913087107. View

Grishman E, White P, Savani R . Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes. Pediatr Res. 2012; 71(6):626-32. DOI: 10.1038/pr.2012.24. View

Garlanda C, Dinarello C, Mantovani A . The interleukin-1 family: back to the future. Immunity. 2013; 39(6):1003-18. PMC: 3933951. DOI: 10.1016/j.immuni.2013.11.010. View

10.

Moller J, Paul D, Ganser G, Range U, Gahr M, Kelsch R . IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). Clin Exp Rheumatol. 2011; 28(6):912-8. View

11.

Makrinioti H, Toussaint M, Jackson D, Walton R, Johnston S . Role of interleukin 33 in respiratory allergy and asthma. Lancet Respir Med. 2014; 2(3):226-37. DOI: 10.1016/S2213-2600(13)70261-3. View

12.

Feng Q, Li P, Leung P, Auersperg N . Caspase-1zeta, a new splice variant of the caspase-1 gene. Genomics. 2004; 84(3):587-91. DOI: 10.1016/j.ygeno.2004.06.005. View

13.

. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell. 1997; 90(4):797-807. DOI: 10.1016/s0092-8674(00)80539-5. View

14.

Rathinam V, Jiang Z, Waggoner S, Sharma S, Cole L, Waggoner L . The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010; 11(5):395-402. PMC: 2887480. DOI: 10.1038/ni.1864. View

15.

Baroja-Mazo A, Martin-Sanchez F, Gomez A, Martinez C, Amores-Iniesta J, Compan V . The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 2014; 15(8):738-48. DOI: 10.1038/ni.2919. View

16.

Lin X, Choi M, Porter A . Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. J Biol Chem. 2000; 275(51):39920-6. DOI: 10.1074/jbc.M007255200. View

17.

Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin J, Humphries S . The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998; 102(7):1369-76. PMC: 508984. DOI: 10.1172/JCI2629. View

18.

Chae J, Cho Y, Lee G, Cheng J, Liu P, Feigenbaum L . Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity. 2011; 34(5):755-68. PMC: 3129608. DOI: 10.1016/j.immuni.2011.02.020. View

19.

Franchi L, Amer A, Body-Malapel M, Kanneganti T, Ozoren N, Jagirdar R . Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol. 2006; 7(6):576-82. DOI: 10.1038/ni1346. View

20.

Lamkanfi M, Dixit V . Mechanisms and functions of inflammasomes. Cell. 2014; 157(5):1013-22. DOI: 10.1016/j.cell.2014.04.007. View