Age-specific Percentile-based Reference Curve of Serum Procalcitonin Concentrations in Japanese Preterm Infants

Overview

Journal Sci Rep

Specialty Science

Date 2016 Apr 2

PMID 27033746

Citations 15

Authors

Noriko Fukuzumi

Kayo Osawa

Itsuko Sato

Sota Iwatani

Ruri Ishino

Nobuhide Hayashi

Kazumoto Iijima

Jun Saegusa

Ichiro Morioka

Affiliations

Soon will be listed here.

Abstract

Procalcitonin (PCT) levels are elevated early after birth in newborn infants; however, the physiological features and reference of serum PCT concentrations have not been fully studied in preterm infants. The aims of the current study were to establish an age-specific percentile-based reference curve of serum PCT concentrations in preterm infants and determine the features. The PCT concentration peaked in infants at 1 day old and decreased thereafter. At 1 day old, serum PCT concentrations in preterm infants <34 weeks' gestational age were higher than those in late preterm infants between 34 and 36 weeks' gestational age or term infants ≥37 weeks' gestational age. Although the 50-percentile value in late preterm and term infants reached the adult normal level (0.1 ng/mL) at 5 days old, it did not in preterm infants. It took 9 weeks for preterm infants to reach it. Serum PCT concentrations at onset in late-onset infected preterm infants were over the 95-percentile value. We showed that the physiological feature in preterm infants was significantly different from that in late preterm infants, even in those <37 weeks' gestational age. To detect late-onset bacterial infection and sepsis, an age-specific percentile-based reference curve may be useful in preterm infants.

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