The Role of MiRNAs in the Regulation of Pancreatic Cancer Stem Cells

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2016 Mar 24

PMID 27006664

Citations 13

Authors

Sabrina Bimonte

Antonio Barbieri

Maddalena Leongito

Giuseppe Palma

Vitale Del Vecchio

Michela Falco

Raffaele Palaia

Vittorio Albino

Mauro Piccirillo

Alfonso Amore

Antonella Petrillo

Vincenza Granata

Francesco Izzo

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

Citing Articles

Identification of Tissue miRNA Signatures for Pancreatic Ductal Adenocarcinoma.

Caputo C, Falco M, Grimaldi A, Lombardi A, Miceli C, Cocule M Cancers (Basel). 2024; 16(4).

PMID: 38398215 PMC: 10887387. DOI: 10.3390/cancers16040824.

Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma.

Bubin R, Uljanovs R, Strumfa I Int J Mol Sci. 2023; 24(8).

PMID: 37108193 PMC: 10138709. DOI: 10.3390/ijms24087030.

Epithelial-mesenchymal transition: a hallmark in pancreatic cancer stem cell migration, metastasis formation, and drug resistance.

Safa A J Cancer Metastasis Treat. 2021; 6.

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The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance.

Patil K, Khan F, Akhtar S, Ahmad A, Uddin S Cancer Metastasis Rev. 2021; 40(3):691-720.

PMID: 34453639 PMC: 8556195. DOI: 10.1007/s10555-021-09979-x.

Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance.

Keyvani-Ghamsari S, Khorsandi K, Rasul A, Zaman M Clin Epigenetics. 2021; 13(1):120.

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