Two Years Changes in the Development of Caudate Nucleus Are Involved in Restricted Repetitive Behaviors in 2-5-year-old Children with Autism Spectrum Disorder

Overview

Journal Dev Cogn Neurosci

Publisher Elsevier

Specialties Neurology
Psychiatry

Date 2016 Mar 22

PMID 26999477

Citations 18

Authors

Ting Qiu

Chen Chang

Yun Li

Lu Qian

Chao Yong Xiao

Ting Xiao

Xiang Xiao

Yun Hua Xiao

Kang Kang Chu

Mark H Lewis

Xiaoyan Ke

Affiliations

Soon will be listed here.

Abstract

Caudate nucleus volume is enlarged in autism spectrum disorder (ASD) and is associated with restricted and repetitive behaviors (RRBs). However, the trajectory of caudate nucleus volume in RRBs of young children remains unclear. Caudate nucleus volume was measured in 36 children with ASD and 18 matched 2-3-year-old subjects with developmentally delayed (DD) at baseline (Time 1) and at 2-year follow-up (Time 2). The differential growth rate in caudate nucleus volume was calculated. Further, the relationships between the development of caudate nucleus volume and RRBs were analyzed. Our results showed that caudate nucleus volume was significantly larger in the ASD group at both time points and the magnitude of enlargement was greater at Time 2. The rate of caudate nucleus growth during this 2-year interval was faster in children with ASD than DD. Right caudate nucleus volume growth was negatively correlated with RRBs. Findings from this study suggest developmental abnormalities of caudate nucleus volume in ASD. Longitudinal MRI studies are needed to explore the correlation between atypical growth patterns of caudate nucleus and phenotype of RRBs.

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