Antimalarial Drug Resistance: An Overview

Overview

Journal Trop Parasitol

Specialty Parasitology

Date 2016 Mar 22

PMID 26998432

Citations 62

Authors

Hiasindh Ashmi Antony

Subhash Chandra Parija

Affiliations

Soon will be listed here.

Abstract

Malaria is a major public health burden throughout the world. Resistance to the antimalarial drugs has increased the mortality and morbidity rate that is achieved so far through the malaria control program. Monitoring the drug resistance to the available antimalarial drugs helps to implement effective drug policy, through the in vivo efficacy studies, in vitro drug susceptibility tests and detection of molecular markers. It is important to understand the mechanism of the antimalarial drugs, as it is one of the key factors in the emergence and spread of drug resistance. This review summarizes the commonly used antimalarial drugs, their mechanism of action and the genetic markers validated so far for the detection of drug-resistant parasites.

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