Models of Inflammation: Carrageenan Air Pouch

Overview

Journal Curr Protoc Pharmacol

Publisher Wiley

Specialties Biochemistry
Pharmacology

Date 2016 Mar 21

PMID 26995549

Citations 18

Authors

Djane B Duarte

Michael R Vasko

Jill C Fehrenbacher

Affiliations

Soon will be listed here.

Abstract

The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, the resolution of the inflammatory response, the oxidative stress response, and potential therapeutic targets for treating inflammation. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti-inflammatory drugs.

Citing Articles

Evaluation of Bioactive Compounds, Antioxidant Capacity, and Anti-Inflammatory Effects of Lipophilic and Hydrophilic Extracts of the Pericarp of var. at Two Stages of Ripening.

Justil-Guerrero H, Arroyo-Acevedo J, Rojas-Armas J, Garcia-Bustamante C, Palomino-Pacheco M, Almonacid-Roman R Molecules. 2024; 29(20).

PMID: 39459332 PMC: 11510094. DOI: 10.3390/molecules29204964.

Novel Regioisomeric Analogues of Naphthyl--Acylhydrazone Derivatives and Their Anti-Inflammatory Effects.

da Costa Salome D, de Freitas R, Fraga C, Fernandes P Int J Mol Sci. 2022; 23(21).

PMID: 36362349 PMC: 9657883. DOI: 10.3390/ijms232113562.

Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds.

Moniot A, Braux J, Siboni R, Guillaume C, Audonnet S, Allart-Simon I Int J Mol Sci. 2022; 23(13).

PMID: 35806233 PMC: 9266889. DOI: 10.3390/ijms23137226.

Synergistic Antibacterial Effect of Zinc Oxide Nanoparticles and Polymorphonuclear Neutrophils.

Ye K, Huang M, He X, An Z, Qin H J Funct Biomater. 2022; 13(2).

PMID: 35466217 PMC: 9036266. DOI: 10.3390/jfb13020035.

Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis.

Aoun M, Cai X, Xu B, Lahore G, Bonner M, He Y Antioxidants (Basel). 2022; 11(1).

PMID: 35052516 PMC: 8773064. DOI: 10.3390/antiox11010012.