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Pathologic Activation of Thrombopoietin Receptor and JAK2-STAT5 Pathway by Frameshift Mutants of Mouse Calreticulin

Overview
Journal Leukemia
Specialties Hematology
Oncology
Date 2016 Mar 19
PMID 26987905
Citations 30
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References
1.
Passamonti F, Caramazza D, Maffioli M . JAK inhibitor in CALR-mutant myelofibrosis. N Engl J Med. 2014; 370(12):1168-9. DOI: 10.1056/NEJMc1400499. View

2.
Kohlhuber F, ROGERS N, Watling D, Feng J, Guschin D, Briscoe J . A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses. Mol Cell Biol. 1997; 17(2):695-706. PMC: 231795. DOI: 10.1128/MCB.17.2.695. View

3.
Klampfl T, Gisslinger H, Harutyunyan A, Nivarthi H, Rumi E, Milosevic J . Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013; 369(25):2379-90. DOI: 10.1056/NEJMoa1311347. View

4.
Chachoua I, Pecquet C, El-Khoury M, Nivarthi H, Albu R, Marty C . Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood. 2015; 127(10):1325-35. DOI: 10.1182/blood-2015-11-681932. View

5.
Michalak M, Corbett E, Mesaeli N, Nakamura K, Opas M . Calreticulin: one protein, one gene, many functions. Biochem J. 1999; 344 Pt 2:281-92. PMC: 1220642. View