Carnosic Acid Slows Photoreceptor Degeneration in the Pde6b(rd10) Mouse Model of Retinitis Pigmentosa

Overview

Journal Sci Rep

Specialty Science

Date 2016 Mar 11

PMID 26961159

Citations 23

Authors

Kai Kang

Matthew J Tarchick

Xiaoshan Yu

Craig Beight

Ping Bu

Minzhong Yu

Affiliations

Soon will be listed here.

Abstract

The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. Carnosic acid (CA) upregulates endogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative models affecting the brain. In this study, we examined the potential effect of CA on photoreceptor death in the Pde6b(rd10) mouse model of RP. Our data shows that CA provided morphological and functional preservation of photoreceptors. CA appears to exert its neuroprotective effects through inhibition of oxidative stress and endoplasmic reticulum stress.

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