The Current State of the Art of Quantitative Phosphoproteomics and Its Applications to Diabetes Research

Overview

Journal Expert Rev Proteomics

Publisher Informa Healthcare

Date 2016 Mar 10

PMID 26960075

Citations 9

Authors

Chi Yuet Xavia Chan

Marina A Gritsenko

Richard D Smith

Wei-Jun Qian

Affiliations

Soon will be listed here.

Abstract

Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been implicated in various human diseases. Kinases and their cognate inhibitors have been considered as hotspots for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for diseases of interest. This review highlights recent advances in phosphoproteomics, the current state of the art of the technologies and the challenges and future perspectives of this research area. Finally, some exemplary applications of phosphoproteomics in diabetes research are underscored.

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