Plasmodium Falciparum Ookinetes Migrate Intercellularly Through Anopheles Stephensi Midgut Epithelium

Overview

Journal Parasitol Res

Specialty Parasitology

Date 1989 Jan 1

PMID 2695921

Citations 20

Authors

J F Meis

G Pool

G J van Gemert

A H Lensen

T Ponnudurai

J H Meuwissen

Affiliations

Soon will be listed here.

Abstract

The migration of Plasmodium falciparum and P. berghei ookinetes through the midgut epithelium in Anopheles stephensi was studied by transmission electron microscopy. With ruthenium red (RR) staining, the results of previous studies were confirmed: P. falciparum ookinetes take an intercellular route through the midgut epithelium. In the same mosquito species, the rodent parasite P. berghei appeared to take an intracellular position, as previously suggested by other authors. The intra- or intercellular ookinete migration of P. berghei or P. falciparum, respectively, can perhaps be related to the higher mortality of P. berghei-infected mosquitoes within the first 2 days of infection. Evidence is presented that oocyst capsule formation begins as early as during the migration of the ookinete. After localization between the epithelial cells and the midgut basal lamina, the rapidly expanding oocyst stretches the overlying layer of the latter at the haemocoelic surface while a new basal lamina is generated between the oocyst and epithelial cell.

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