Pronephric Tubule Formation in Zebrafish: Morphogenesis and Migration

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2016 Mar 5

PMID 26942753

Citations 8

Authors

Richard W Naylor

Alan J Davidson

Affiliations

Soon will be listed here.

Abstract

The nephron is the functional subunit of the vertebrate kidney and plays important osmoregulatory and excretory roles during embryonic development and in adulthood. Despite its central role in kidney function, surprisingly little is known about the molecular and cellular processes that control nephrogenesis. The zebrafish pronephric kidney, comprising two nephrons, provides a visually accessible and genetically tractable model system for a better understanding of nephron formation. Using this system, various developmental processes, including the commitment of mesoderm to a kidney fate, renal tubule proliferation, and migration, can be studied during nephrogenesis. Here, we discuss some of these processes in zebrafish with a focus on the pathways that influence renal tubule cell morphogenesis.

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