Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2010 Apr 10

PMID 20378823

Citations 64

Authors

Eric D de Groh

Lisa M Swanhart

Chiara Cianciolo Cosentino

Rachel L Jackson

Weixiang Dai

Carolyn A Kitchens

Billy W Day

Thomas E Smithgall

Neil A Hukriede

Affiliations

Soon will be listed here.

Abstract

One of the first hallmarks of kidney regeneration is the reactivation of genes normally required during organogenesis. Identification of chemicals with the potential to enhance this reactivation could therapeutically promote kidney regeneration. Here, we found that 4-(phenylthio)butanoic acid (PTBA) expanded the expression domains of molecular markers of kidney organogenesis in zebrafish. PTBA exhibits structural and functional similarity to the histone deacetylase (HDAC) inhibitors 4-phenylbutanoic acid and trichostatin A; treatment with these HDAC inhibitors also expanded the renal progenitor cell population. Analyses in vitro and in vivo confirmed that PTBA functions as an inhibitor of HDAC activity. Furthermore, PTBA-mediated renal progenitor cell expansion required retinoic acid signaling. In summary, these results support a mechanistic link among renal progenitor cells, HDAC, and the retinoid pathway. Whether PTBA holds promise as a therapeutic agent to promote renal regeneration requires further study.

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