B Cell Sub-types Following Acute Malaria and Associations with Clinical Immunity

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2016 Mar 5

PMID 26939776

Citations 23

Authors

Richard T Sullivan

Isaac Ssewanyana

Samuel Wamala

Felistas Nankya

Prasanna Jagannathan

Jordan W Tappero

Harriet Mayanja-Kizza

Mary K Muhindo

Emmanuel Arinaitwe

Moses Kamya

Grant Dorsey

Margaret E Feeney

Eleanor M Riley

Chris J Drakeley

Bryan Greenhouse

Richard Sullivan

Affiliations

Soon will be listed here.

Abstract

Background: Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria.

Methods: To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria-lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia.

Results: Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria.

Conclusions: These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.

Citing Articles

Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults.

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Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.

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Generation of plasma cells and CD27IgD B cells during hantavirus infection is associated with distinct pathological findings.

Kerkman P, Dernstedt A, Tadala L, Mittler E, Dannborg M, Sundling C Clin Transl Immunology. 2021; 10(7):e1313.

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