Integrated Metabolomics and Metagenomics Analysis of Plasma and Urine Identified Microbial Metabolites Associated with Coronary Heart Disease

Overview

Journal Sci Rep

Specialty Science

Date 2016 Mar 3

PMID 26932197

Citations 77

Authors

Qiang Feng

Zhipeng Liu

Shilong Zhong

RuiJun Li

Huihua Xia

Zhuye Jie

Bo Wen

Xiaomin Chen

Wei Yan

Yanqun Fan

Zhenyu Guo

Nan Meng

Jiyan Chen

Xiyong Yu

Zhiwei Zhang

Karsten Kristiansen

Jun Wang

Xun Xu

Kunlun He

Guanglei Li

Affiliations

Soon will be listed here.

Abstract

Coronary heart disease (CHD) is top risk factor for health in modern society, causing high mortality rate each year. However, there is no reliable way for early diagnosis and prevention of CHD so far. So study the mechanism of CHD and development of novel biomarkers is urgently needed. In this study, metabolomics and metagenomics technology are applied to discover new biomarkers from plasma and urine of 59 CHD patients and 43 healthy controls and trace their origin. We identify GlcNAc-6-P which has good diagnostic capability and can be used as potential biomarkers for CHD, together with mannitol and 15 plasma cholines. These identified metabolites show significant correlations with clinical biochemical indexes. Meanwhile, GlcNAc-6-P and mannitol are potential metabolites originated from intestinal microbiota. Association analysis on species and function levels between intestinal microbes and metabolites suggest a close correlation between Clostridium sp. HGF2 and GlcNAc-6-P, Clostridium sp. HGF2, Streptococcus sp. M143, Streptococcus sp. M334 and mannitol. These suggest the metabolic abnormality is significant and gut microbiota dysbiosis happens in CHD patients.

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