Discovery of Novel Sesquistilbene Indanone Analogues As Potent Anti-inflammatory Agents

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2016 Feb 29

PMID 26922229

Citations 8

Authors

Mei-Lin Tang

Chen Zhong

Zheng-Yu Liu

Peng Peng

Xin-Hua Liu

Xun Sun

Affiliations

Soon will be listed here.

Abstract

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.

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