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Thin Film Differential Photosensor for Reduction of Temperature Effects in Lab-on-Chip Applications

Overview
Journal Sensors (Basel)
Publisher MDPI
Specialty Biotechnology
Date 2016 Feb 25
PMID 26907292
Authors
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Abstract

This paper presents a thin film structure suitable for low-level radiation measurements in lab-on-chip systems that are subject to thermal treatments of the analyte and/or to large temperature variations. The device is the series connection of two amorphous silicon/amorphous silicon carbide heterojunctions designed to perform differential current measurements. The two diodes experience the same temperature, while only one is exposed to the incident radiation. Under these conditions, temperature and light are the common and differential mode signals, respectively. A proper electrical connection reads the differential current of the two diodes (ideally the photocurrent) as the output signal. The experimental characterization shows the benefits of the differential structure in minimizing the temperature effects with respect to a single diode operation. In particular, when the temperature varies from 23 to 50 °C, the proposed device shows a common mode rejection ratio up to 24 dB and reduces of a factor of three the error in detecting very low-intensity light signals.

References
1.
Pais A, Banerjee A, Klotzkin D, Papautsky I . High-sensitivity, disposable lab-on-a-chip with thin-film organic electronics for fluorescence detection. Lab Chip. 2008; 8(5):794-800. DOI: 10.1039/b715143h. View

2.
Matos Pires N, Dong T, Hanke U, Hoivik N . Recent developments in optical detection technologies in lab-on-a-chip devices for biosensing applications. Sensors (Basel). 2014; 14(8):15458-79. PMC: 4178989. DOI: 10.3390/s140815458. View

3.
Kamei T, Paegel B, Scherer J, Skelley A, Street R, Mathies R . Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices. Anal Chem. 2004; 75(20):5300-5. DOI: 10.1021/ac0301550. View

4.
Diakite M, Champ J, Descroix S, Malaquin L, Amblard F, Viovy J . A low-cost, label-free DNA detection method in lab-on-chip format based on electrohydrodynamic instabilities, with application to long-range PCR. Lab Chip. 2012; 12(22):4738-47. DOI: 10.1039/c2lc40372b. View

5.
Mirasoli M, Nascetti A, Caputo D, Zangheri M, Scipinotti R, Cevenini L . Multiwell cartridge with integrated array of amorphous silicon photosensors for chemiluminescence detection: development, characterization and comparison with cooled-CCD luminograph. Anal Bioanal Chem. 2014; 406(23):5645-56. DOI: 10.1007/s00216-014-7971-9. View