Interplay of Endoplasmic Reticulum Stress and Autophagy in Neurodegenerative Disorders

Overview

Journal Autophagy

Specialty Cell Biology

Date 2016 Feb 24

PMID 26902584

Citations 120

Authors

Yu Cai

Jyothi Arikkath

Lu Yang

Ming-Lei Guo

Palsamy Periyasamy

Shilpa Buch

Affiliations

Soon will be listed here.

Abstract

The common underlying feature of most neurodegenerative diseases such as Alzheimer disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) involves accumulation of misfolded proteins leading to initiation of endoplasmic reticulum (ER) stress and stimulation of the unfolded protein response (UPR). Additionally, ER stress more recently has been implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Autophagy plays an essential role in the clearance of aggregated toxic proteins and degradation of the damaged organelles. There is evidence that autophagy ameliorates ER stress by eliminating accumulated misfolded proteins. Both abnormal UPR and impaired autophagy have been implicated as a causative mechanism in the development of various neurodegenerative diseases. This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.

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